Calcium channel blockers

• Autores: Ian Whyte, Nick Buckley, Andrew Dawson
• Localización: Medicine, ISSN-e 1357-3039, Vol. 44, Nº. 3, 2016, págs. 148-150
• Idioma: inglés
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• Resumen

  • Overdose of calcium channel blockers is potentially lethal. Verapamil and diltiazem are much more dangerous than dihydropyridines. Hypotension with (verapamil and diltiazem) or without (dihydropyridines) heart block and bradycardia are the most important features. Routine management usually comprises intravenous fluids, activated charcoal, whole-bowel irrigation (for modified-release products) and prolonged electrocardiographic monitoring. Antidotes for cardiac effects include calcium, bicarbonate, high-dose insulin–euglycaemia and vasopressors with atropine and/or transvenous pacing in cases of symptomatic bradycardia.