Phenobarbital – a beneficial eight-hourly dosing option?

• Autores: Annette Wessmann
• Localización: Veterinary Record, ISSN-e 2042-7670, Vol. 180, Nº. 7, 2017
• Idioma: inglés
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• Resumen

  • Idiopathic epilepsy is the most common neurological medical condition in dogs with an estimated prevalence of 0.6 per cent presenting to first-opinion practice in the UK (Kearsley-Fleet and others 2013). About two-thirds of dogs with idiopathic epilepsy are controlled with one or a combination of two medications. Phenobarbital remains the most commonly used first-line antiepileptic drug in dogs affected by idiopathic epilepsy, and achieves sufficient seizure control in about two-thirds of affected dogs when used as a single agent (Packer and others 2015, Tipold and others 2015). The phenobarbital doses used in individual epileptic dogs are largely modified based on the seizure frequency, phenobarbital serum levels and the drug side effects. Drug formularies generally advise a 12-hourly phenobarbital oral dosing regime (Plumb 2008, Ramsey 2014).