Resumen de Dosing of Etelcalcetide vs Cinacalcet for Secondary Hyperparathyroidism—Reply
Geoffrey A. Block, Glenn M. Chertow
In Reply Dr Hai and colleagues are concerned that the starting dose of etelcalcetide was 5 mg (not the lowest dose) whereas the starting dose of cinacalcet was 30 mg (the lowest dose). This clinical trial, using a double-dummy active control, dosed cinacalcet in strict accordance with the approved package insert and in a manner consistent with previous clinical trials of similar duration using similar biochemical end points.1,2 Our finding of a mean decrease in PTH of approximately 40% over 26 weeks in patients treated with cinacalcet is similar to findings of the phase 3 trials with cinacalcet (43% decrease in mean PTH over 26 weeks).1 The dosing of etelcalcetide was approved by the US Food and Drug Administration. Because cinacalcet and etelcalcetide are different drugs, there is no a priori reason to believe that their dosing schemes should be identical.
