The ties that bind: mapping the dynamic enhancer-promoter interactome

• Cailyn H. Spurrell ^[1] ; Diane E. Dickel ^[1] ; Axel Visel ^[2]
  1. [1] Lawrence Berkeley National Laboratory

     Lawrence Berkeley National Laboratory

     Estados Unidos

     
  2. [2] Joint Genome Institute

     Joint Genome Institute

     Estados Unidos

     
• Localización: Cell, ISSN 0092-8674, Vol. 167, Nº. 5, 2016, págs. 1163-1166
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Coupling chromosome conformation capture to molecular enrichment for promoter-containing DNA fragments enables the systematic mapping of interactions between individual distal regulatory sequences and their target genes. In this Minireview, we describe recent progress in the application of this technique and related complementary approaches to gain insight into the lineage- and cell-type-specific dynamics of interactions between regulators and gene promoters.