Association between oral HSV-1 and survival in allogeneic hematopoietic stem cell transplanted patients

• Andre Luiz Sena Guimaraes ^[1] ; Carolina Cavalieri Gomes ^[1] ; Luciano Marques da Silva ^[2] ; Jeane de Fatima Correia-Silva ^[2] ; Junia Maria Neto Victoria ^[2] ; Ricardo Santiago Gomez ^[2] ; Henrique Bittencourt ^[3]
  1. [1] Universidade Estadual de Montes Claros

     Universidade Estadual de Montes Claros

     Brasil

     
  2. [2] Universidade Federal de Minas Gerais

     Universidade Federal de Minas Gerais

     Brasil

     
  3. [3] Hospital das Clinicas, Brazil

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• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 14, Nº. 2 (February), 2009
• Idioma: inglés
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• Resumen

  • Introduction: This study was designed to investigate the effect of oral HSV-1 shedding on the survival of allogeneic hematopoietic stem cell transplanted (allo-HSCT) patients.

    Methods: One hundred nineteen allo-HSCT patients were included in the study and divided in three groups: before transplant, 100 days after transplant and 1 year of allo-HSCT. Healthy volunteers matched by age and gender were also selected. Oral swabs were performed and the nested PCR was used to detect HSV-1 presence in the oral mucosa. In statistical analysis, chi-square test was used to test the distribution of HSV1 shedding among the three groups. Time to death after allo-HSCT was displayed by means of the Kaplan-Meier method and the results were compared by the log-rank test. Cox proportional hazards multivariate model was used to evaluate the survival.

    Results: We observed that HSV-1 shedding was similar at different points after allo-HSCT. However, HSV-1 shedding before allo-HSCT was associated with worst survival rates after allo-HSCT in multivariate analysis.

    Conclusion: Our data demonstrates that HSV-1 shedding in oral mucosa before transplant is associated with worst survival rate of allo-HSCT patients.