Giant cell angiofibroma of the oral cavity: a case report and review of the literature

• Cleverton Roberto de Andrade ^[1] ; Márcio Ajudarte Lopes ^[2] ; Oslei Paes de Almeida ^[2] ; Jorge Esquiche León ^[2] ; Florence Mistro ^[2] ; Sergio Kignel ^[1]
  1. [1] Centro Universitário Herminio Ometto de Araras

     Centro Universitário Herminio Ometto de Araras

     Brasil

     
  2. [2] UNICAMP, Piracicaba, São Paulo, Brazil
• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 13, Nº. 9 (September), 2008
• Idioma: inglés
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• Resumen

  • Giant cell angiofibroma is a well-circumscribed, normally encapsulated, distinctive orbital soft tissue tumor. However, it is now recognized that this lesion can also present in other locations, including the oral cavity. The morphological hallmark is a richly vascularized, patternless spindle cell proliferation containing pseudovascular spaces and floret-type multinucleate giant cells. CD34 immunoreactivity, although not specific, represents the only immunohistochemical finding of potential diagnostic value. We present a case of a 44-year-old male Caucasian patient complaining of painless solitary nodule arising on the right buccal mucosa, which was diagnosed as giant cell angiofibroma. To the best of our knowledge, this is the third case of oral giant cell angiofibroma reported in the English-language literature.