Thymic Determinants of γδ T Cell Differentiation

• Autores: Miguel Muñoz Ruiz, Nital Sumaria, Daniel J. Pennington, Bruno Silva Santos
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 38, Nº. 5, 2017, págs. 336-344
• Idioma: inglés
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• Resumen

  • γd T cells have emerged as major sources of the proinflammatory cytokines interleukin-17 (IL-17) and interferon-γ (IFNγ) in multiple models of infection, cancer and autoimmune disease. However, unlike their αβ T cell counterparts that require peripheral activation for effector cell differentiation, γδ T cells instead can be ‘developmentally programmed’ in the thymus to generate discrete γδ T cell effector subsets with distinctive molecular signatures. Nonetheless, recent studies have presented conflicting viewpoints on the signals involved in thymic γδ T cell development and differentiation, namely on the role of both T cell receptor (TCR)-dependent and TCR-independent factors. Here we review the current data and the ongoing controversies.