IL-17 Signaling: The Yin and the Yang

• Autores: Nilesh Amatya, Abhishek D. Garg, Sarah L Gaffen
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 38, Nº. 5, 2017, págs. 310-322
• Idioma: inglés
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• Resumen

  • Interleukin (IL)-17 is the founding member of a novel family of inflammatory cytokines. While the proinflammatory properties of IL-17 are key to its host-protective capacity, unrestrained IL-17 signaling is associated with immunopathology, autoimmune disease, and cancer progression. In this review we discuss both the activators and the inhibitors of IL-17 signal transduction, and also the physiological implications of these events. We highlight the surprisingly diverse means by which these regulators control expression of IL-17-dependent inflammatory genes, as well as the major target cells that respond to IL-17 signaling.