Lymph Node Stroma Dynamics and Approaches for Their Visualization

• Autores: Rebecca Gentek, Marc Bajénoff
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 38, Nº. 4, 2017, págs. 236-247
• Idioma: inglés
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• Resumen

  • Lymphoid stromal cells are best known as the architectural cells of lymphoid organs. For decades, they have been considered as inert elements of the immune system but this view has changed dramatically in recent years, when it was discovered that they are endowed with critical immunoregulatory functions. It is now accepted that without them, the adaptive immune response would be compromised, if not abrogated entirely. Here, we review the function of the major lymphoid stromal cell types; the way they remodel upon inflammation; discuss the available tools to track their behavior; and introduce several methodological approaches that we believe will help improving our knowledge of these pivotal cell types.