Clinicopathologic analysis of 14 cases of odontogenic myxoma and review of the literature

• Ana-Lucia-Noronha Francisco ^[1] ; Thiago-Celestino Chulam ^[2] ; Fábio-Oliveira Silva ^[3] ; Diogo-Gonçalves Ribeiro ^[3] ; Clóvis-Antônio-Lopes Pinto ^[4] ; Rogério-Oliveira Gondak ^[5] ; Luiz-Paulo Kowalski ^[2] ; João Gonçalves-Filho ^[2]
  1. [1] DDS, PhD, Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, Brazil
  2. [2] MD, PhD, Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, Brazil
  3. [3] MD, Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, Brazil
  4. [4] MD, PhD, Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil
  5. [5] DDS, PhD, Department of Pathology, Federal University of Santa Catarina, Florianópolis, Brazil

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• Localización: Journal of Clinical and Experimental Dentistry, ISSN-e 1989-5488, Vol. 9, Nº. 4 (Abril), 2017, págs. 560-563
• Idioma: inglés
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• Resumen

  • Odontogenic myxoma is a rare benign neoplasm that originates from odontogenic ectomesenchyme. There is no standard of care and recurrences are frequent after conservative surgical procedures.

    A retrospective study conducted at a single cancer center, with analysis of medical records of all patients diagnosed with odontogenic myxoma from 1980 to 2010, along with a literature review.

    There were 14 patients with diagnosis of odontogenic myxoma (OM). Most patients were female (78.6%) and Caucasian (100%), with ages ranging from 7 to 51 years (21.6 ± 11.6 years). The time period between the first symptom and first consultation ranged from 0 to 60 months (19.4 ± 19.97 months). The most frequent complaints were increased local volume or failure to tooth eruption. The most common tumor site was the mandible (11 cases, 78.5%). About radiological findings, most lesions were multilocular (9 cases, 64.3%) and with imprecise limits (12 cases, 85.7%). Surgery was performed in all cases and curettage was the most applied technique (10 cases, 71.4%). Three patients underwent mandibulectomy and complex reconstructions including iliac crest microvascular flap. Three patients had postoperative complications and 4 had local recurrences of the tumor. The follow up time ranged from 12 to 216 months (112 ± 70.8 months). All patients are without clinical and radiographic evidence of disease.

    OM is a locally aggressive and rare tumor. There is no gold standard surgical management and the therapeutic decision should be individualized taking into account the characteristics and extension of the tumor.