Epstein-Barr virus in oral proliferative verrucous leukoplakia and squamous cell carcinoma: a preliminary study

• Jose V. Bagan ^[3] ; Yolanda Jiménez ^[3] ; Judith Murillo ^[3] ; Rafael Poveda ^[3] ; José M. Diaz ^[3] ; Carmen Gavaldá ^[3] ; María Margaix ^[3] ; Crispian Scully ^[1] ; Trinidad M. Alberola ; Manuela Torres Puente ; Manuel Pérez Alonso ^[2]
  1. [1] University College London

     University College London

     Reino Unido

     
  2. [2] Universitat de València

     Universitat de València

     Valencia, España

     
  3. [3] University General Hospital, Valencia

  Mostrar afiliaciones +
• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 13, Nº. 2, 2008
• Idioma: inglés
• Enlaces
  • Texto completo (pdf)
• Resumen

  • The aim of this study was to analyze proliferative verrucous leukoplakia (PVL) and oral squamous cell carcinoma (OSCC) for the possible presence of Epstein-Barr virus (EBV).

    We studied three groups: Sub-Group 1 was composed of 10 patients with PVL, (6 of whom had developed OSCC);

    Sub-Group 2 comprised 5 patients with OSCC but no preceding PVL; and Sub-Group 3 were 5 controls with clinically normal oral mucosa. Oral biopsies from all cases were examined for Epstein-Barr virus (EBV) by nested PCR.

    EBV was detected in 60% of Sub-Group 1 patients (PVL ) and in 40% of Sub-Group 2 (OSCC), but in 0% of SubGroup 3 (controls).