Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 YearsThe VDAART Randomized Clinical Trial
- Autores: Augusto A. Litonjua, Vincent J. Carey, Nancy Laranjo
- Localización: JAMA: the journal of the American Medical Association, ISSN 0098-7484, Vol. 315, Nº. 4, 2016, págs. 362-370
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Importance Asthma and wheezing begin early in life, and prenatal vitamin D deficiency has been variably associated with these disorders in offspring.
Objective To determine whether prenatal vitamin D (cholecalciferol) supplementation can prevent asthma or recurrent wheeze in early childhood.
Design, Setting, and Participants The Vitamin D Antenatal Asthma Reduction Trial was a randomized, double-blind, placebo-controlled trial conducted in 3 centers across the United States. Enrollment began in October 2009 and completed follow-up in January 2015. Eight hundred eighty-one pregnant women between the ages of 18 and 39 years at high risk of having children with asthma were randomized at 10 to 18 weeks’ gestation. Five participants were deemed ineligible shortly after randomization and were discontinued.
