Effect of Vitamin D3 Supplementation During Pregnancy on Risk of Persistent Wheeze in the OffspringA Randomized Clinical Trial

• Autores: Bo L. Chawes, Klaus Bønnelykke, Jakob Stokholm
• Localización: JAMA: the journal of the American Medical Association, ISSN 0098-7484, Vol. 315, Nº. 4, 2016, págs. 353-361
• Idioma: inglés
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• Resumen

  • Importance Observational studies have suggested that increased dietary vitamin D intake during pregnancy may protect against wheezing in the offspring, but the preventive effect of vitamin D supplementation to pregnant women is unknown.

    Objective To determine whether supplementation of vitamin D3 during the third trimester of pregnancy reduces the risk of persistent wheeze in the offspring.

    Design, Setting, and Participants A double-blind, single-center, randomized clinical trial conducted within the Copenhagen Prospective Studies on Asthma in Childhood 2010 cohort. Enrollment began March 2009 with a goal of 708 participants, but due to delayed ethical approval, only 623 women were recruited at 24 weeks of pregnancy. Follow-up of the children (N = 581) was completed when the youngest child reached age 3 years in March 2014.

    Interventions Vitamin D3 (2400 IU/d; n = 315) or matching placebo tabl