Interferon-I: The Pièce de Résistance of HIV-1 Transmission?

• Autores: Damien C. Tully, Daniel T. Claiborne, Todd M. Allen
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 25, Nº. 5, 2017, págs. 332-334
• Idioma: inglés
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• Resumen

  • Despite the extensive viral quasispecies that develops in an individual during the course of HIV-1 infection, transmission is typically established by a single donor viral variant. Recent studies now provide insight into the phenotypic properties influencing this selection process at transmission, including the contribution of resistance to type I interferons.