Bioengineered 3D Models for Studying Human Cell–Tuberculosis Interactions

• Autores: Sulayman Benmerzoug, Valerie F.J. Quesniaux
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 25, Nº. 4, 2017, págs. 245-246
• Idioma: inglés
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• Resumen

  • In vivo animal models have intrinsic limitations for studying relationships between tuberculosis and its host and there is a need for alternative, in vitro cellular models. A microsphere-based 3D in vitro culture system of Mycobacterium tuberculosis-infected human blood mononuclear cells was reported to address specific aspects of host–pathogen interactions.