The expression of Smad signaling pathway in myocardium and potential therapeutic effects

• Yuping Duan ^[1] ; Wei Zhu ^[1] ; Min Liu ^[2] ; Muhammad Ashraf ^[2] ; Meifeng Xu ^[2]
  1. [1] Jiangsu University

     Jiangsu University

     China

     
  2. [2] University of Cincinnati

     University of Cincinnati

     City of Cincinnati, Estados Unidos

     
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 32, Nº. 7, 2017, págs. 651-659
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Myocardial infarction (MI) is a life-threatening disease. The expression of Smad proteins in the ischemic myocardium changes significantly following myocardial infarction, suggesting a close relationship between Smad proteins and heart remodeling. Moreover, it is known that the expression of Smads is regulated by transforming growth factor-β (TGF-β) and bone morphogenetic proteins (BMP). Based on these findings, regulating the expression of Smad proteins by targeting TGF-β and BMP in the ischemic myocardium may be considered to be a possible therapeutic strategy for the treatment of myocardial infarction