Binary mixtures of midazolam and furosemide stored in continuous infusion systems: Compatibility and stability

• Autores: María Espinosa Bosch, Fuensanta Sánchez Rojas, Catalina Bosch Ojeda
• Localización: European journal of clinical pharmacy: atención farmacéutica, ISSN 2385-409X, Vol. 18, Nº. 6, 2016, págs. 407-410
• Idioma: inglés
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• Resumen

  • Objectives: The mixture of different drugs for use in continuous infusion systems is a common practice in palliative care, but the analytical study of compatibility and stability is not always available. The objective of this research is to study the midazolam-furosemide mixture solutions at different concentrations and temperatures prepared in 0.9% NaCl and stored into infusers and glass, all of them protected from light.

    Method: The samples were prepared and diluted in NaCl 0.9% in elastomeric infusor and glass in triplicate to obtain six different conditions of concentration and/or temperature of storage (concentration: 0.3 mg/mL-0.6 mg/mL; 0.3 mg/mL- 0.7 mg/mL and 0.35 mg/mL-0.6 mg/mL of midazolam and furosemide respectively;

    temperature of storage 25 ºC and 37 ºC). The concentration of each constituent drug into different mixtures was periodically determined using a HPLC-UV method. The drugs were chromatographied on a C18 reverse phase column; the mobile phase was acetonitrile-water 80:20 (v/v); flow rate 1.5 mL/min. Rt(furosemide) = 1.5 min and Rt(midazolam) = 2.3 min. Midazolam and furosemide concentrations were determined at 235 nm by interpolation from the calibration curves prepared at (0, 1, 2, 3, 7, 11, 15) days from the standards. Statgraphics centurion XVI program has been used to data treatment.

    Key findings: The stability of the admixtures diluted in NaCl 0.9% is as follow: midazolam-furosemide (0.3 mg/mL-0.6 mg/mL) is stable (retaining more than 95% of the initial concentration) during 17 days at 25 ºC and <24 hours at 37 ºC; (0.3 mg/mL-0.7 mg/mL) is stable <24 hours at both temperatures; (0.35 mg/mL-0.6 mg/mL) is stable <24 hours at both temperatures. Admixtures stored into glass their stabilities are higher.

    Conclusions: This study was proven to be suitable for determining the stability and compatibility of midazolam and furosemide mixtures in elastomeric infusors and glass. It may be applied to stablish the stability of different samples prepared in NaCl 0.9% and stored at two temperatures and can be used in palliative care