Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling

• Autores: John R. Teijaro, Cherie Ng, Andrew M. Lee
• Localización: Science, ISSN 0036-8075, Vol. 340, Nº 6129, 2013, págs. 208-211
• Idioma: inglés
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• Resumen

  • During persistent viral infections, chronic immune activation, negative immune regulator expression, an elevated interferon signature, and lymphoid tissue destruction correlate with disease progression. We demonstrated that blockade of type I interferon (IFN-I) signaling using an IFN-I receptor neutralizing antibody reduced immune system activation, decreased expression of negative immune regulatory molecules, and restored lymphoid architecture in mice persistently infected with lymphocytic choriomeningitis virus. IFN-I blockade before and after establishment of persistent virus infection resulted in enhanced virus clearance and was CD4 T cell–dependent. Hence, we demonstrate a direct causal link between IFN-I signaling, immune activation, negative immune regulator expression, lymphoid tissue disorganization, and virus persistence. Our results suggest that therapies targeting IFN-I may help control persistent virus infections.