Evolución a largo plazo de la esquizofrenia de inicio tardío: estudio de 5 años de seguimiento

H. Brodaty ^[1] ; P. Sachdev ^[1] ; A. Koschera ^[1] ; D. Monk ^[1] ; B. Cullen ^[1]
1. [1] Prince of Wales Hospital
  
  Prince of Wales Hospital
  
  Australia
Localización: Psiquiatría biológica: Publicación oficial de la Sociedad Española de Psiquiatría Biológica, ISSN 1134-5934, Vol. 11, Nº. 3, 2004, págs. 79-86
Idioma: español
Títulos paralelos:
- Long-term outcome of late-onset schizophreniA: 5-year follow-up study
Texto completo no disponible (Saber más ...)

Resumen
- Background: There is controversy about whether late-onset schizophrenia is a precursor of cognitive decline. Aims: To examine the long-term outcome of a group of patients with late-onset schizophrenia. Patients and method: Patients with onset of DSM-III-R schizophrenia at age 50 years or over, but without dementia, and a healthy control group were assessed at baseline (n=27 and and n=34, respectively), after 1 year and after 5 years (n=19 and n=24, respectively) on measures of psychopathology, cognition and general functioning, and compared on rates of decline and incidence of dementia. Results: Nine patients with late-onset schizophrenia and none of the control group were found to have dementia (5 Alzheimer type, 1 vascular, 3 dementia of unknown type) at 5-year follow-up. There appeared to be a subgroup of late-onset schizophrenia patients without onset signs of dementia at baseline or at1 year follow-up who subsequently declined. Conclusions: Late-onset schizophrenia may be a prodrome of Alzheimer-type dementia. More longitudinal studies are required to determine its nosological status.