Heterogeneous circulating angiogenic cell responses to acute maximal exercise

• Autores: Daniel D. Shill, Meagan P. Marshburn, Hannah K. Hempel
• Localización: Medicine & Science in Sports & exercise: Official Journal of the American College of Sports Medicine, ISSN 0195-9131, Vol. 48, Nº. 12, 2016, págs. 2536-2543
• Idioma: inglés
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• Resumen

  • AB Purpose: Circulating angiogenic cells (CAC) comprise multiple subpopulations of exercise-inducible peripheral blood mononuclear cells (PBMC) that promote angiogenesis and maintain endothelial integrity. We examined the effect of acute maximal exercise on CD31+, CD62E+, CD14+/CD31+, CD34+/VEGFR2+, CD3+/CD31+, and CD3+ PBMC in young, healthy adults. Methods: Blood samples were collected before and immediately after a graded treadmill exercise test for CAC analysis via flow cytometry. Results: Maximal exercised produced 40%, 29%, 33%, 14%, and 33% increases in lymphocytic CD31+, monolymphocytic CD31+, CD62E+, CD14+/CD31+, and CD34+/VEGFR2+ PBMC, respectively (P < 0.05). CD3+/CD31+ and CD3+ cells were not altered with exercise. CD62E+ and CD14+/CD31+ PBMC were selectively augmented in women by 54% and 20%, respectively (P < 0.05). Exploratory analyses indicated that maximal exercise induced greater increases in CD62E+ and CD14+/CD31+ PBMC among women in the luteal phase compared with those in the follicular phase (P < 0.05). Basal lymphocytic PBMC and postexercise lymphocytic and monolymphocytic CD31+ PBMC were lower among contraceptive users than nonusers. Conclusions: Maximal exercise induces a robust CAC response encompassing both progenitor and nonprogenitor cell types, with these effects differing between men and women for CD62E+ and CD14+/CD31+ cell types and the potential influence of menstrual cycle phase and contraceptive use. (C) 2016 American College of Sports Medicine