Inflammatory mediators and signalling pathways controlling intervertebral disc degeneration

• Stefania Elena Navone ^[1] ; Giovanni Marfia ^[1] ; Amedeo Giannoni ^[1] ; Matteo Beretta ^[1] ; Laura Guarnaccia ^[1] ; Roberta Gualtierotti ^[1] ; Daniele Nicoli ^[1] ; Paolo Rampini ^[1] ; Rolando Campanella ^[1]
  1. [1] University of Milan

     University of Milan

     Milán, Italia

     
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 32, Nº. 6, 2017, págs. 523-542
• Idioma: inglés
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• Resumen

  • Intervertebral disc (IVD) degeneration (IDD) is one of the major causes of back pain, a condition that represents a serious socio-economic burden. Deeper knowledge of the complex and fine relationship between IVD degeneration, tissue inflammation and pain, appears to be critical to improve the current therapies, which have so far proven themselves ineffective. Upon degeneration, IVD tissues become inflamed, and this inflammatory microenvironment is associated with a cascade of degenerative events that may eventually cause discogenic pain. In particular, several studies have highlighted the major role of a number of pro-inflammatory mediators not only in the onset of the inflammatory condition, but also in the development of IDD in general. In this review, we will present the main pathological events that occur during disc degeneration, focusing on the relationship between the abnormal inflammatory milieu of the degenerating IVD, IDD and the generation of pain. Finally, we will present the current therapies for the treatment of IDD and low back pain, and the perspectives of future, more effective therapies