Photoredox Activation for the Direct β-Arylation of Ketones and Aldehydes

• Autores: Michael T. Pirnot, Danica A. Rankic
• Localización: Science, ISSN 0036-8075, Vol. 339, Nº 6127, 2013, págs. 1594-1596
• Idioma: inglés
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• Resumen

  • The direct β-activation of saturated aldehydes and ketones has long been an elusive transformation. We found that photoredox catalysis in combination with organocatalysis can lead to the transient generation of 5π-electron β-enaminyl radicals from ketones and aldehydes that rapidly couple with cyano-substituted aryl rings at the carbonyl β-position. This mode of activation is suitable for a broad range of carbonyl β-functionalization reactions and is amenable to enantioselective catalysis.