DNA Gridiron Nanostructures Based on Four-Arm Junctions

• Autores: Dongran Han, Suchetan Pal, Yang Yang, Shuoxing Jiang
• Localización: Science, ISSN 0036-8075, Vol. 339, Nº 6126, 2013, págs. 1413-1415
• Idioma: inglés
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• Resumen

  • Engineering wireframe architectures and scaffolds of increasing complexity is one of the important challenges in nanotechnology. We present a design strategy to create gridiron-like DNA structures. A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons were assembled, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects.