Endothelin Signaling in Bone

• Jasmin Kristianto ^[1] ; Michael G. Johnson ^[3] ; Rafia Afzal ^[2] ; Robert D. Blank ^[1]
  1. [1] Medical College of Wisconsin

     Medical College of Wisconsin

     City of Milwaukee, Estados Unidos

     
  2. [2] Aga Khan University Hospital

     Aga Khan University Hospital

     Pakistán

     
  3. [3] University of Wisconsin

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• Localización: Endocrinology and metabolism clinics of North America, ISSN 0889-8529, Vol. 46, Nº. 1, 2017, págs. 51-62
• Idioma: inglés
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• Resumen

  • The endothelin (ET) system includes 3 small peptide hormones and a pair of G-protein–coupled receptors. This review first outlines the ET signaling pathway and ET metabolism. Next, it summarizes the role of ET1 signaling in craniofacial development. Then, it discusses observations relating ET signaling to osteoblastic and other osteosclerotic processes in cancer. Finally, it describes recent work in our laboratory that points to endothelin signaling as an upstream mediator of WNT signaling, promoting bone matrix synthesis and mineralization. It concludes with a statement of some remaining gaps in knowledge and proposals for future research.