A complication arising in the design of small experiments involving mixture or process variables is that these experiments are often conducted using split-plot designs that lead to correlated observations. It is shown how algorithmic search can be used to construct tailor-made split-plot mixture-process designs when there might be constraints on the mixture components. The D-optimality criterion is the main design criterion used. In addition, it is shown how to construct split-plot mixture-process variable designs when replication is required for estimating variance components.
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