A1C and Diabetes Diagnosis: The Rancho Bernardo Study

• Autores: Caroline K. Kramer, Maria Rosario G. Araneta, Elizabeth Barrett-Connor
• Localización: Diabetes care, ISSN-e 0149-5992, Vol. 33, Nº. 1 (ENE), 2010, págs. 101-103
• Idioma: inglés
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• Resumen

  • To examine the sensitivity and specificity of A1C as a diagnostic test for type 2 diabetes in older adults. Cross-sectional study of community-dwelling adults without known diabetes who had an oral glucose tolerance test and A1C measured on the same day. Mean age of the 2, 107 participants was 69.4 ¡À 11.1 years; 43% were men. Based on the American Diabetes Association (ADA) criteria, 198 had previously undiagnosed type 2 diabetes. The sensitivity/specificity of A1C cut point of 6.5% was 44/79%. Results were similar in age- and sex-stratified analyses. Given the A1C cut point of 6.5%, 85% of participants were classified as nondiabetic by ADA criteria. The limited sensitivity of the A1C test may result in delayed diagnosis of type 2 diabetes, while the strict use of ADA criteria may fail to identify a high proportion of individuals with diabetes by A1C ¡Ý6.5% or retinopathy.