Chapter Nine - Oral GLP-1 Modulators for the Treatment of Diabetes

• Autores: David J. Edmonds, David A. Price
• Localización: Annual reports in medicinal chemistry, ISSN 0065-7743, Vol 48, 2013, págs. 119-130
• Idioma: inglés
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• Resumen

  • Abstract This review covers recent (2009–Jan 2013) developments in the field of orally administered glucagon-like peptide 1 receptor (GLP-1R) agonists for the treatment of diabetes. Several approaches are discussed, namely formulation approaches for oral administration of peptides, the use of transporters for active uptake of peptide drugs, and small molecule GLP-1R agonists.