Resumen de Chapter Eight - Current Approaches to the Treatment of Atrial Fibrillation
Abstract Atrial fibrillation (AF) is a condition characterized by rapid and irregular sinus rhythm which leads to a higher incidence of stroke and increased mortality. AF affects approximately 1% of the worldwide population, and despite significant advances in anticoagulation therapy, AF patients remain in abnormal sinus rhythm. There is a demonstrated benefit to restoring and maintaining normal sinus rhythm in addition to preventing thromboembolic events, and the discovery of anti-arrhythmic agents with improved efficacy and safety has been a continued and active area of research in the pharmaceutical industry. Recent clinical and preclinical advances in the atrial-selective IKur and IKAch ion channel targets are summarized in this review covering disclosures from 2010 to 2014.
