Lisinopril has a cardio-protective effect on experimental acute autoimmune myocarditis in rats
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Muhammad Atteya [1] ; Raeesa A. Mohamed [1] ; Aly M. Ahmed [1] ; Nayira A. Abdel-Baky [3] ; Musaad A. Alfayez [1] ; Hatim D. Almalke [1] ; Ahmed F. El Fouhil [2]
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[1] King Saud University
King Saud University
Arabia Saudí
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[2] Ain Shams University
Ain Shams University
Egipto
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[3] Al-Azhar University
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- Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 32, Nº. 4, 2017, págs. 405-412
- Idioma: inglés
- Enlaces
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Resumen
The present study investigated the effect of lisinopril on experimental autoimmune myocarditis (EAM) in rats, a histologically similar model to human acute myocarditis. Animals & Methods: Twenty four, six week-old male Wistar rats were randomly allocated into 4 groups of 6 rats each. Group I received no treatment. Group II received lisinopril at a dose of 15 mg/kg/day suspended in 1 ml of 2% gum acacia daily, from day 1 to day 21. To induce myocarditis, animals of groups III and IV were injected by 1 mg of porcine cardiac myosin on days 1 and 8. In addition, animals of group IV received lisinopril in gum acacia daily, from day 1 to day 21. All rats were sacrificed on day 21. Serum levels of creatine phosphokinase, troponin-T, tumor necrosis factor-α and interleukin-6 were estimated. Hearts were processed for histopathological, as well as immunohistochemical study for thioredoxin (TRX) immunoreactivity. Results: The wall of hearts from rats of myocarditis-lisinopril group showed mild focal myocarditis and a significant decrease of the mean percentage of pyknotic nuclei in cardiomyocytes, coincident with a significant decrease in serum biomarkers levels and TRX immunoreactivity, compared to myocarditis group. Conclusion: The present study suggested a cardio-protective effect of lisinopril on acute EAM in rats, probably through a mechanism related to its suppressive effect on angiotensin II formation
