Quantitative Analysis of Multicomponent Mixtures of Over-the-Counter Pain Killer Drugs by Low-Field NMR Spectroscopy

• Aleksandra Zivkovic ^[1] ; Jan Josef Bandolik ^[1] ; Alexander Jan Skerhut ^[1] ; Christina Coesfeld ^[1] ; Momir Prascevic ^[2] ; Ljiljana Zivkovic ^[2] ; Holger Stark ^[1]
  1. [1] Heinrich Heine University Düsseldorf

     Heinrich Heine University Düsseldorf

     Kreisfreie Stadt Düsseldorf, Alemania

     
  2. [2] University of Nis

     University of Nis

     Serbia

     
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 94, Nº 1, 2017, págs. 121-125
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Marketed pain relief drugs with one to three biologically active components, as well as mixtures of these ingredients, were qualitatively and quantitatively analyzed in an undergraduate student lab using a compact, low-field 1H NMR spectrometer. The students successfully analyzed more than 50 self-made sample mixtures with two or three components as well as the two marketed tablet formulations containing acetylsalicylic acid/l-ascorbic acid, or acetylsalicylic acid/paracetamol (acetaminophen)/caffeine. The NMR-based quantification is an attractive application of the technique, as well as a helpful introduction to NMR spectroscopic applications in life sciences. Problem-based learning on NMR techniques on commonly known drugs provided students the opportunity to develop and improve their skills in solving 1H NMR problems.