Evaluation of Postmortem Cerebrospinal Fluid S100B Protein and Serotonin Levels: Comparison of Suicidal Versus Nonsuicidal Deaths in Konya, Turkey

• Kamil Hakan Dogan ^[1] ; Mustafa Unaldi ^[3] ; Serafettin Demirci ^[2]
  1. [1] Konya Food and Agriculture University

     Konya Food and Agriculture University

     Turquía

     
  2. [2] Necmettin Erbakan University

     Necmettin Erbakan University

     Turquía

     
  3. [3] Department of Biochemistry Private Ticaret Borsasi Hospital Konya Turkey

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• Localización: Journal of forensic sciences, ISSN-e 1556-4029, ISSN 0022-1198, Vol. 61, Nº. 5, 2016, págs. 1285-1291
• Idioma: inglés
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• Resumen

  • Although suicide is a preventable public health problem, objective assays for suicide risk are limited. In this study, it was aimed to determine levels of S100B protein and serotonin as a marker for risk of suicide. S100B protein and serotonin levels were investigated with ELISA method in the cerebrospinal fluid (CSF) in medicolegal autopsy cases, including those of suicide cases (n = 32) and nonsuicide cases (n = 56). The CSF S100B levels were higher (9.3 +- 2.9 ng/mL vs. 5.4+- 2.0 ng/mL), and serotonin levels were lower (10.4+- 4.9 ng/mL vs. 19.0+- 5.7 ng/mL) in suicide group than nonsuicide group (p < 0.05). There was no correlation between S100B protein and serotonin levels with gender, age groups, postmortem interval, and cause of death. It is concluded that both S100B protein and serotonin in CSF may be useful for determination of suicide risk.