The Gut Microbiota: The Gateway to Improved Metabolism

• Autores: Kristina B. Martinez, Joseph F. Pierre, Eugene B. Chang
• Localización: Gastroenterology clinics of North America, ISSN 0889-8553, Vol. 45, Nº. 4, 2016 (Ejemplar dedicado a: Obesity and Gastroenterology), págs. 601-614
• Idioma: inglés
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• Resumen

  • Obesity is an emerging global epidemic with profound challenges to world health care economies and societies. Traditional approaches to fighting obesity have not shown promise in promoting a decline in obesity prevalence. The gut microbiota is becoming widely appreciated for its role in regulating metabolism and thus represents a target for new therapies to combat obesity and associated comorbidities. This article provides an overview of altered microbial community structure in obesity, dietary impact on the gut microbiota, host-microbe interactions contributing to the disease, and improvements in microbial assemblage after bariatric surgery and with therapies targeting the gut microbiome.