Morphological changes in the rat carotid body 1, 2, 4, and 8 weeks after the termination of chronically hypocapnic hypoxia

T. Kusakabe; H. Hirakawa; S. Oikawa; H. Matsuda; T. Kawakami; T. Takenawa; Y. Hayashida

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Morphological changes in the rat carotid body 1, 2, 4, and 8 weeks after the termination of chronically hypocapnic hypoxia

T. Kusakabe ^[4] ; H. Hirakawa ^[1] ; S. Oikawa ^[5] ; H. Matsuda ^[2] ; T. Kawakami ^[3] ; T. Takenaka ^[4] ; Y. Hayashida ^[6]
1. [1] National Defense Medical College
  
  National Defense Medical College
  
  Minuma-ku, Japón
2. [2] Yokohama City University
  
  Yokohama City University
  
  Naka Ku, Japón
3. [3] Kitasato University
  
  Kitasato University
  
  Japón
4. [4] Kokushikan University
  
  Kokushikan University
  
  Japón
5. [5] Labour Welfare Corporation Ehime Rosai, Hospital, Ehime
6. [6] International Buddhist University, Osaka, Japan
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Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 19, Nº. 4, 2004, págs. 1133-1140
Idioma: inglés
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- Morphological changes in the rat carotid bodies 1, 2, 4, and 8 weeks after the termination of chronically hypocapnic hypoxia (10% O2 for 8 weeks) were examined by means of morphometry and immunohistochemistry. The rat carotid bodies after 8 weeks of hypoxic exposure were enlarged several fold with vascular expansion. The carotid bodies 1 and 2 weeks after the termination of 8 weeks of hypoxic exposure were diminished in size, although their diameter remained larger than the normoxic controls. The expanded vasculature in chronically hypoxic carotid bodies returned to the normoxic control state. In the carotid bodies 1 week after the termination of chronic hypoxia, the density of NPY fibers was remarkably increased and that of VIP fibers was dramatically decreased in comparison with the density in chronically hypoxic carotid bodies. In the carotid bodies 2 and 4 weeks after the termination of hypoxia, the density of SP and CGRP fibers was gradually increased. In the carotid bodies 8 weeks after the termination of hypoxia, the appearance of the carotid body returned to a nearly normoxic state, and the density of SP, CGRP, VIP, and NPY fibers also recovered to that of normoxic controls. These results suggest that the morphological changes in the recovering carotid bodies start at a relatively early period after the termination of chronic hypoxia, and a part of these processes may be under the control of peptidergic innervation.