Resumen de Biocatalyzed Regioselective Synthesis in Undergraduate Organic Laboratories: Multistep Synthesis of 2-Arachidonoylglycerol
Meghan R. Johnston, Alexandros Makriyannis, Kyle M. Whitten, Olivia C. Drew, Fiona A. Best
In order to introduce the concepts of biocatalysis and its utility in synthesis to organic chemistry students, a multistep synthesis of endogenous cannabinergic ligand 2-arachidonoylglycerol (2-AG) was tailored for use as a laboratory exercise. Over four weeks, students successfully produced 2-AG, purifying and characterizing products at each stage of the reaction series. This synthetic series also reinforces the importance of executing reactions under inert atmosphere, the strategic placement of protecting groups, and regioselectivity.
