Serum vitamin D levels decrease in children with acute urticaria
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[1] Başkent University
Başkent University
Turquía
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- Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 44, Nº. 6, 2016, págs. 512-516
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Background Acute urticaria is an immune-inflammatory disease, characterised by acute immune activation. There has been increasing evidence showing that vitamin D deficiency is associated with increased incidence and severity of immune-inflammatory disorders.
Objective The aim of this study was to evaluate serum vitamin D levels in acute urticaria.
Methods We enrolled 30 children with acute urticaria and 30 control subjects. Concentrations of 25-hydroxyvitamin D [25(OH)D], a biomarker of vitamin D status, were measured in serum of acute urticaria patients and compared with the control group.
Results There were no significant differences in baseline variables (age, gender, weight) between the groups. Vitamin D deficiency (<20 ng/ml) was significantly higher in patients with acute urticaria than in control patients. Serum 25(OH)D levels were significantly lower in the study group compared to those in the control group (13.1 ± 4.3 vs 28.2 ± 7.4 ng/mL, p < 0.05). Moreover, we found negative correlation between mean duration of acute urticaria and serum vitamin D levels (p < 0.01).
Conclusion This study revealed a significant association of lower serum 25(OH)D concentrations with acute urticaria and an inverse relationship with disease duration. These findings may open up the possibility of the clinical use of vitamin D as a contributing factor in the pathogenesis of acute urticaria and a predictive marker for disease activity in acute urticaria. A potential role of vitamin D in pathogenesis and additive therapy in acute urticaria needs to be examined.
