Resumen de Homotopic reciprocal functional connectivity between anterior human insulae.

Nuria Lacuey, Bilal Zonjy, Emine S Kahriman, Ahmad Marashly, Jonathan Miller, Samden D Lhatoo, Hans O Lüders

• The aim of this study was to investigate functional connectivity between right and left insulae in the human brain. We studied a patient with implanted depth electrodes for epilepsy surgery evaluation with stereotactically placed symmetric depth electrodes in both insulae. Bipolar 1 Hz electrical stimulation of the right and left posterior short gyri in the anterior insula evoked responses in the contralateral insular structures. These responses showed a latency of 8-24 ms. This report demonstrates for the first time bi-directional homotopic and heterotopic functional connectivity between right and left anterior insulae. The short latency of the evoked responses suggests mono- or oligo-synaptic connections, most likely via the corpus callosum.;