An RNA twist to TH17 cells

• Autores: Maninjay K. Atianand, Katherine A. Fitzgerald
• Localización: Science, ISSN 0036-8075, Vol. 351, Nº 6277, 2016, págs. 1032-1032
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • T helper lymphocytes play essential roles in the adaptive immune system. They come in distinct types defined by unique transcriptional programs that control their development and functions. Among these, T helper 17 (TH17) cells are important in protecting mucosal surfaces against fungal and bacterial infections. In addition, TH17 cells contribute to the pathogenesis of multiple autoimmune diseases (1). A recent study (2) adds yet another layer of complexity to the biology of these complex cells—an RNA helicase and a long noncoding RNA (lncRNA) that act together to control their effector functions.