Primary oral melanoma: a histopathological and immunohistochemical study of 22 cases of Latin America

Bruno Augusto Benevenuto de Andrade; Víctor Hugo Toral Rizo; Jorge Esquiche León; Elisa Contreras Vidaurre; Román Carlos; Wilson A. Delgado Azañero; Adalberto Mosqueda Taylor; Oslei Paes de Almeida

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Primary oral melanoma: a histopathological and immunohistochemical study of 22 cases of Latin America

Bruno A B. de-Andrade ^[3] ; Víctor H. Toral-Rizo ^[3] ; Jorge E. León ^[4] ; Elisa Contreras ^[5] ; Román Carlos ^[6] ; Wilson Delgado-Azañero ^[1] ; Adalberto Mosqueda-Taylor ^[2] ; Oslei P. de-Almeida ^[4]
1. [1] Universidad Peruana Cayetano Heredia
  
  Universidad Peruana Cayetano Heredia
  
  Perú
2. [2] Universidad Autónoma Metropolitana
  
  Universidad Autónoma Metropolitana
  
  México
3. [3] DDS, MSc. Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil
4. [4] DDS, PhD. Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil
5. [5] DDS, MSc. Centro Clínico de Cabeza y Cuello, Ciudad de Guatemala, Guatemala
6. [6] DDS. Centro Clínico de Cabeza y Cuello, Ciudad de Guatemala, Guatemala
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Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 17, Nº. 3 (Mayo), 2012
Idioma: inglés
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Resumen
- Objective: The aim of this study was to analyze the histopathological and immunohistochemical characteristics of 22 cases of primary oral melanomas (OM).
  
  Study Design: Twenty two cases of primary oral melanoma were analyzed by description of their histopathological features and immunohistochemical study using the antibodies S-100, HMB-45, Melan-A and Ki-67.
  
  Results: The mean age was 58 years and 14 cases were female. The main affected sites were the hard palate, followed by the upper gingiva. Microscopically, 15 cases presented level III of invasion, 2 cases were amelanotic and 13 showed a mixed epithelioid and plasmacytoid or spindle cells composition. Some cases showed necrosis, perivascular and perineural invasion. S-100 and HMB-45 were positive in all cases, but 3 cases were negative for Melan-A. The proliferative index with Ki-67 was high, with labeling index ranging from 15.51% to 63% of positive cells.
  
  Conclusion: S-100 and HMB-45 are more frequently expressed than Melan-A in primary oral melanomas and these markers are helpful to confirm the diagnosis.