Resumen de Concentraciones circulantes de MCP-1, VEGF-A, sICAM-1, sVCAM-1, sE-selectina y sVE-cadherina: su relación con componentes del síndrome metabólico en población joven

Iris Paola Guzmán Guzmán, Óscar Zaragoza García, Amalia Vences Velázquez, Natividad Castro Alarcón, José Francisco Muñoz Valle, Isela Parra Rojas

• español

  En esta revista Número actual Avance Online Números anteriores Suplementos Índice por secciones Los más leídos FI 2015 1,267 © Thomson Reuters, Journal Citation Reports, 2015 Sobre la revista Envío de manuscritos Comité Editorial Normas de Publicación Información de la Revista Contactar Indexada en:

  Current Contents/Clinical Medicine, Journal Citation Reports, SCI-Expanded, Index Medicus/Medline, Excerpta Medica/EMBASE, IBECS, IME, MEDES, PASCAL, SCOPUS, ScienceDirect Métricas Factor de Impacto: 1,267(2015) 5-años Factor de Impacto: 1,344 SCImago Journal Rank (SJR):0,22 Source Normalized Impact per Paper (SNIP):0,385 Vol. 147. Núm. 10. Noviembre 2016 Documento Anterior - Documento Siguiente doi: 10.1016/j.medcli.2016.06.028 Original Concentraciones circulantes de MCP-1, VEGF-A, sICAM-1, sVCAM-1, sE-selectina y sVE-cadherina: su relación con componentes del síndrome metabólico en población joven Circulating levels of MCP-1, VEGF-A, sICAM-1, sVCAM-1, sE-selectin and sVE-cadherin: Relationship with components of metabolic syndrome in young population Iris Paola Guzmán-Guzmána,, , Oscar Zaragoza-Garcíaa, Amalia Vences-Velázqueza, Natividad Castro-Alarcóna, José Francisco Muñoz-Valleb, Isela Parra-Rojasa a Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, México b Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México Recibido 24 noviembre 2015, Aceptado 30 junio 2016 Resumen

• English

  Introduction Inflammation and endothelial dysfunction are considered the primary manifestations of the cardiovascular disease. Studies have established a relationship among components of metabolic syndrome (MetS) with inflammatory markers and the loss of permeability, vasoconstriction and vasodilatation endothelial.

  Objective To determine the relationship among the concentrations of soluble endothelial dysfunction molecules and inflammation cytokines and components of the metabolic syndrome in young population.

  Material and methods A study was performed in 240 young adult students ages 18-28 years. To define the presence of clinical and metabolic alterations and MetS the modified ATP-III criteria was considered. In all subjects were determined sociodemographic characteristics, anthropometric measures and the metabolic profile. Circulating levels of MCP-1, VEGF-A, sICAM-1, sVCAM-1, sE-selectin and sVE-cadherin were determined by ELISA immunoassay (Bioscience). Statistical analysis was performed using STATA statistical software v. 9.2.

  Results From all the participants, 44.6% had obesity, 59.9% had abdominal obesity, 49.6% low HDL-c and 16.7% high levels triglycerids. The 16.25% of the population showed 3 or more components of the MetS. Elevated MCP-1, sICAM-1 and sE-selectin levels were linked to the presence of obesity. In a model adjusted by age-gender, high soluble levels of MCP-1 and VEGF-A were linked with abdominal obesity (OR=1.83; 1.02-3.28 and OR=2.03; 1.15-3.56, respectively), as well as to the presence of the 2 components of MetS. sVCAM-1 levels were associated with impaired glucose (OR=4.74; 1.32-17.0); sE-selectin with low HDL-c (OR=1.99; 1.05-3.75), although sICAM-1 and sVE-cadherin were associated with impaired systolic blood pressure (OR=4.04; 1.24-13.1 and OR=6.28; 1.90-20.7, respectively).

  Conclusion Levels of circulating MCP-1 and VEGF-A were associated with adiposity, levels of sVCAM-1 with the presence of impaired glucose, sE-selectin with low HDL-c, while the levels of sICAM-1 and sVE-cadherin were associated with impaired systolic blood pressure in young adults independently of other traditional risk factors.