Cardiac troponin I in three cat breeds with hypertrophic cardiomyopathy

• Autores: R. Langhorn
• Localización: Veterinary Record, ISSN-e 2042-7670, Vol. 178, Nº. 21, 2016, pág. 532
• Idioma: inglés
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• Resumen

  • HYPERTROPHIC cardiomyopathy (HCM) is the most common cardiac disease in cats, associated with severe myocardial structural and ultrastructural changes (Abbott 2010, Christiansen and others 2015). In human beings, HCM is frequently inherited as an autosomal dominant trait caused by mutations in genes encoding sarcomeric proteins, including the myosin-binding protein C (MYBPC3) and the cardiac troponins (Gomes and Potter 2004, Cambronero and others 2009). In cats, familial mutations have been described in the MYBPC3 protein in Maine Coons (A31P) and ragdolls (R820W) (Meurs and others 2005, 2007). Cats homozygous for these mutations have a high risk of developing a fatal, progressive HCM (Meurs and others 2005, Borgeat and others 2014b). While additional causative mutations associated with feline HCM have yet to be discovered, several other breeds are considered predisposed.