Epidemiological characteristics of a Spanish cohort of patients diagnosed with squamous cell carcinoma of head and neck: distribution of risk factors by tumor

• R. Seijas-Tamayo ^[1] ; J. Fernández-Mateos ^[1] ; J. C. Adansa Klain ^[1] ; R. Mesía ^[2] ; M. Pastor Borgoñón ^[7] ; E. Pérez-Ruiz ^[3] ; S. Vázquez Fernández ^[2] ; C. Salvador Coloma ^[7] ; A. Rueda Domínguez ^[3] ; M. Taberna ^[2] ; J. Martínez-Trufero ^[4] ; T. Bonfill Abella ^[8] ; S. Vázquez Estévez ^[5] ; M. Pollán ^[6] ; E. del Barco Morillo ^[1] ; J. J. Cruz-Hernández ^[1]
  1. [1] Hospital Universitario de Salamanca

     Hospital Universitario de Salamanca

     Salamanca, España

     
  2. [2] Universitat de Barcelona

     Universitat de Barcelona

     Barcelona, España

     
  3. [3] Hospital Costa Del Sol

     Hospital Costa Del Sol

     Marbella, España

     
  4. [4] Hospital Miguel Servet

     Hospital Miguel Servet

     Zaragoza, España

     
  5. [5] Hospital Universitario Lucus Augusti

     Hospital Universitario Lucus Augusti

     Lugo, España

     
  6. [6] Instituto de Salud Carlos III

     Instituto de Salud Carlos III

     Madrid, España

     
  7. [7] Hospital Universitario Politécnico La Fe, España
  8. [8] Hospital Parc Tauli, España

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• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 18, Nº. 11 (November 2016), 2016, págs. 1114-1122
• Idioma: inglés
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• Dialnet Métricas: 1 Cita
• Resumen

  • Purpose Head and neck cancer is a highly heterogeneous disease comprising a large number of tumors located in the cervicofacial area. This study aimed to determine the epidemiological characteristics of squamous-cell carcinomas of the head and neck in the Spanish population, and the distribution of risk factors based on tumor locations.

    Methods/patients A cohort of 459 patients (75 oral cavity, 167 oro-/hypopharyngeal and 217 laryngeal cancers) recruited in 19 hospitals participating in the Spanish head and neck cancer cooperative group were included over 3 years (2012–2014). Epidemiological parameters and risk factors were obtained from a self-administered questionnaire, and tumor characteristics were obtained from clinical records. Multivariate multinomial logistic regression was used to assess factors associated with tumor location.

    Results Most patients were males (88.4 %), smokers (95 %) and drinkers (76.5 %). Relative to laryngeal cancer, pharyngeal cancer and oral cancer were more common in women than men (OR 3.58, p = 0.003 and 4.33, p = 0.001, respectively); pharyngeal cancer was more associated with rural environment (OR 1.81, p = 0.007) and weekly alcohol intake (10–140 g: OR 2.53, p = 0.012; 141–280 g: OR 2.47, p = 0.023; >280 g: OR 3.20, p = 0.001) and less associated with pack-years of smoking (21–40 packs: OR 0.46, p = 0.045; 41–70 packs: OR 0.43, p = 0.023; ≥71 packs: OR 3.20, p = 0.015).

    Conclusions The distribution of these tumors differs between the sexes, with a higher proportion of oral cavity and pharyngeal tumors in women than in men. Oro-/hypopharyngeal cancers were more strongly associated with rural areas and with alcohol consumption, although less strongly associated with smoking than laryngeal tumors.