First-Line Antibiotics May Worsen MRSA infection

• Autores: Tracy Hampton
• Localización: JAMA: the journal of the American Medical Association, ISSN 0098-7484, Vol. 315, Nº. 1, 2016, págs. 19-19
• Idioma: inglés
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• Resumen

  • New research suggests that treatment of Methicillin-resistant Staphylococcus aureus (MRSA) infections with first-line β-lactam antibiotics not only is ineffective but may be harmful (Muller S et al. Cell Host Microbe. 2015;18[5]:520-522).

    β-Lactam antibiotics eradicate many bacteria by disrupting bacterial cell wall synthesis. However, investigators from Cedars-Sinai Medical Center in Los Angeles found that exposure of MRSA to β-lactam antibiotics activates a gene called mecA, which in turn activates a back-up pathway for cell wall synthesis that can trigger a harmful inflammatory response. In MRSA-infected mice, this led to higher IL-1β levels and neutrophil recruitment, leading to greater immunopathology and more severe skin infections.