Circulating Tumor DNA Helps Track Cancer

• Autores: Tracy Hampton
• Localización: JAMA: the journal of the American Medical Association, ISSN 0098-7484, Vol. 315, Nº. 1, 2016, págs. 19-19
• Idioma: inglés
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• Resumen

  • By comparing biopsy and plasma samples over 3 years from a patient diagnosed with metastatic breast cancer, researchers discovered that circulating tumor DNA can be useful for tracking cancer spread and response to treatment (Murtaza M et al. Nat Commun. 2015;6:8760).

    Using exome and targeted amplicon sequencing techniques, a team led by investigators at the University of Cambridge in the United Kingdom performed genetic analyses of 8 tumor biopsies and 9 plasma samples collected over 1193 days from the patient, who had metastatic estrogen receptor–positive and human epidermal growth factor receptor 2–positive disease and was receiving 2 lines of targeted therapy.