Memory γδ T Cells–Newly Appreciated Protagonists in Infection and Immunity

• Autores: Stephen J. Lalor, Rachel M. McLoughlin
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 37, Nº. 10, 2016, págs. 690-702
• Idioma: inglés
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• Resumen

  • Despite the potential for diversity in their T cell receptor, γδ T cells are primarily considered to be innate immune cells. Recently, memory-like γδ T cell responses have been identified in murine models of infection and autoimmunity. Similar memory responses have also been described in human and non-human primate γδ T cells. It has thus become clear that subpopulations of γδ T cells can develop long-lasting memory akin to conventional αβ T cells, with protective and pathogenic consequences. Hence, a re-evaluation of their true capabilities and role in infection and immunity is required. This review discusses recent reports of memory-type responses attributed to γδ T cells and assesses this underappreciated facet of these enigmatic cells.