Transcription-coupled eviction of histones H2A/H2B governs V(D)J recombination

• Sarah Bevington ^[1] ; Joan Boyes ^[1]
  1. [1] Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 32, Nº. 10, 2013, págs. 1381-1392
• Idioma: inglés
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• Resumen

  • V(D)J recombination in pre-B cells relies on the formation of accessible chromatin at recombination sites through non-coding transcription by the transcription factor IRF4, which evicts histones H2A/H2B.