Resumen de Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels

Ludovic Sauguet, Frédéric Poitevin, Samuel Murail, Catherine van Renterghem, Gustavo Moraga Cid, Laurie Malherbe, Andrew W. Thompson, Patrice Koehl, Pierre-Jean Corringer, Marc Baaden, Marc Delarue

• The high-resolution crystal structure of a pentameric ligand-gated ion channel reveals that hydroxylated residues and two water pentagon rings form an ion selectivity filter, explaining ion transport across hydrophobic constriction barriers.