RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis

• Monika Lichtinger ^[4] ; Richard Ingram ^[4] ; Rebecca Hannah ^[5] ; Dorothee Müller ^[4] ; Deborah Clarke ^[4] ; Salam A Assi ^[1] ; Michael Lie-A-Ling ^[6] ; Laura Noailles ^[4] ; M S Vijayabaskar ^[1] ; Mengchu Wu ^[2] ; Daniel G Tenen ^[3] ; David R Westhead ^[1] ; Valerie Kouskoff ^[6] ; Georges Lacaud ^[6] ; Berthold Göttgens ^[5] ; Constanze Bonifer ^[4]
  1. [1] University of Leeds

     University of Leeds

     Reino Unido

     
  2. [2] Harvard Medical School

     Harvard Medical School

     City of Boston, Estados Unidos

     
  3. [3] National University of Singapore

     National University of Singapore

     Singapur

     
  4. [4] Section of Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
  5. [5] Cambridge Institute of Molecular Medicine, Cambridge, UK
  6. [6] Paterson Institute for Cancer Research, University of Manchester, Manchester, UK

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 22, 2012, págs. 4318-4333
• Idioma: inglés
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• Resumen

  • Correct temporal gene expression patterns and haematopoietic cell fate acquisition are driven by RUNX1-dependent genome-wide reorganization of lineage-specific transcription factors.