Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

• Estela Area-Gomez ^[1] ; Maria del Carmen Lara Castillo ^[1] ; Marc D Tambini ^[1] ; Cristina Guardia-Laguarta ^[1] ; Ad J C de Groof ^[1] ; Moneek Madra ^[1] ; Junichi Ikenouchi ^[2] ; Masato Umeda ^[2] ; Thomas D Bird ^[3] ; Stephen L Sturley ^[1] ; Eric A Schon ^[1]
  1. [1] Columbia University Medical Center

     Columbia University Medical Center

     Estados Unidos

     
  2. [2] Kyoto University

     Kyoto University

     Kamigyō-ku, Japón

     
  3. [3] Division of Neurogenetics, University of Washington and Geriatrics Research Center, VA Medical Center, Seattle, WA, USA

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 21, 2012, págs. 4106-4123
• Idioma: inglés
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• Resumen

  • Alzheimer disease (AD) associated (gamma)-secretase components presenilin-1 and -2 accumulate in MAM, an LR-like ER subcompartment connected to mitochondria. MAM function increases in patients with familial or sporadic AD and may be linked to AD pathogenesis.