Anchored phosphatases modulate glucose homeostasis

• Simon A Hinke ^[1] ; Manuel F Navedo ^[2] ; Allison Ulman ^[1] ; Jennifer L Whiting ^[1] ; Patrick J Nygren ^[1] ; Geng Tian ^[3] ; Antonio J Jimenez-Caliani ^[2] ; Lorene K Langeberg ^[1] ; Vincenzo Cirulli ^[2] ; Anders Tengholm ^[3] ; Mark L Dell'Acqua ^[4] ; L Fernando Santana ^[2] ; John D Scott ^[1]
  1. [1] Howard Hughes Medical Institute

     Howard Hughes Medical Institute

     Estados Unidos

     
  2. [2] University of Washington

     University of Washington

     Estados Unidos

     
  3. [3] Uppsala University

     Uppsala University

     Uppsala domkyrkoförs., Suecia

     
  4. [4] Department of Pharmacology, University of Colorado, Aurora, CO, USA

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 20, 2012, págs. 3991-4004
• Idioma: inglés
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• Resumen

  • AKAP150 knockout- and mutant knock-in alleles reveal an unexpected role of the adaptor in anchoring phosphatase 2B for efficient insulin secretion from pancreatic β-cells and thus glucose homeostasis.