Resumen de The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension

Judith J Smit, Davide Monteferrario, Sylvie M Noordermeer, Willem J van Dijk, Bert A van der Reijden, Titia K. Sixma

• Like Parkin, the linear ubiquitin chain assembly complex LUBAC functions as a RING/HECT-hybrid ubiquitin ligase, but includes a unique extension that dictates linear ubiquitin linkage specificity.